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Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

Frontiers of Medicine doi: 10.1007/s11684-023-1037-3

Abstract: So far, a few small-molecule antiviral drugs, including nirmatrelvir–ritonavir (Paxlovid), remdesivirTo date, four domestically developed oral anti-COVID-19 drugs have been granted conditional market approvalThese drugs include azvudine, simnotrelvir–ritonavir (Xiannuoxin), leritrelvir, and mindeudesivir (VV116pharmacological mechanism and therapeutic effects focusing on mindeudesivir and other small-molecule antiviralunderstanding and highlight the potential widespread application of China’s homegrown anti-COVID-19 drugs

Keywords： COVID-19     antiviral drugs     mindeudesivir    

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Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection

Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 404-415 doi: 10.1007/s11684-021-0834-9

Abstract: Although various strategies have been used to study anti-ZIKV agents, approved drugs or vaccines forRepurposing clinically approved drugs could be an effective approach to quickly respond to an emergencyThe well-established safety profiles and optimal dosage of these clinically approved drugs could providefocuses on the recent research and development of agents against ZIKV infection by repurposing clinical drugs

Keywords： Zika virus     clinical drugs     ZIKV inhibitors     antivirals     repurposing    

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Direct acting antiviral-induced dynamic reduction of serum

Tung Huynh, Ke-Qin Hu

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 658-666 doi: 10.1007/s11684-019-0707-7

Abstract: Direct acting antiviral (DAA) treatments may reduce the elevated α fetoprotein (AFP), but data on how

Keywords： chronic hepatitis C     α fetoprotein     direct acting antiviral treatment     cirrhosis    

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ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1, doi: 10.15302/J-FASE- 2021390

Abstract: NK0238 exhibited useful antiviral activities against a variety of viruses both in greenhouse and field

Keywords： antiviral plant protectant / antiviral in the greenhouse / field evaluation / l-trp-NCA / synthesis optimization    

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Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 3,   Pages 305-309 doi: 10.1007/s11705-009-0021-z

Abstract: Their potent antiviral properties indicated the prospect of new drugs.

Keywords： benzimidazole     coxsackie virus B3     antiviral properties    

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ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT

Wentao XU, Hao TIAN, Hongjian SONG, Yuxiu LIU, Yongqiang LI, Qingmin WANG

Frontiers of Agricultural Science and Engineering   Pages 110-119 doi: 10.15302/J-FASE-2021390

Abstract: NK0238 exhibited useful antiviral activities against a variety of viruses both in greenhouse and field

Keywords： antiviral plant protectant     antiviral in the greenhouse     field evaluation     L-trp-NCA     synthesis optimization    

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Occurrence, distribution and risk assessment of abused drugs and their metabolites in a typical urban

Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 4, doi: 10.1007/s11783-019-1140-5

Abstract:

We developed a method for determining 11 abused drugs in water and

METH and EPH were the dominant drugs in water

Abuse drugs in Beiyunhe River were mainly from

Abused drugs in the water would not impair the

Keywords： Drugs of abuse     Occurrence     Distribution     Urban river     Environmental risk    

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Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 260-267 doi: 10.15302/J-FASE-2016116

Abstract: The innate immune response is the first line of defense against viral invasion and pro-inflammatory chemokines and cytokines have a critical function in the innate immune responses against virus infections. The ability of a rabies virus (RABV) to induce the expression of chemokines and cytokines can lead to viral clearance from the central nervous system (CNS), whereas the ability to evade such expression and activation contributes to virulence and pathogenicity. In this review, the crucial contribution of chemokines/cytokines to clearing RABV from the CNS is discussed, including recruiting leukocytes into the CNS, enhancement of blood brain barrier permeability and activation of various immune cells that are essential for viral clearance. In addition, recombinant RABV expressing cytokines and chemokines can induce elevated innate and adaptive immune responses which result in clearing an established wild-type RABV infection in the CNS.

Keywords： antiviral     blood brain barrier     chemokines and cytokines     innate immunity     rabies virus    

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ANTIVIRAL EFFECTS OF BACTERIOCIN AGAINST ANIMAL-TO-HUMAN TRANSMITTABLE MUTATED SARS-COV-2: A SYSTEMATIC

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 4,   Pages 603-622 doi: 10.15302/J-FASE -2021397

Abstract: Despite possessing antiviral traits the potential of bacteriocins to combat SARS-CoV-2 infection hasThese antimicrobial peptides have been suggested as effective antiviral therapeutics and therapeuticSpecific attention is given to the antiviral mechanisms of the molecules along with their integrative

Keywords： antimicrobial proteins / antiviral profiling of bacteriocins / antiviral therapeutics / immunomodulation    

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Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 815-826 doi: 10.1007/s11684-021-0891-0

Abstract: Oral drugs such as ibrutinib play an important role in the treatment of mature B-cell lymphoma (BCL)Hematology, Chinese Medical Association conducted an extensive discussion and reached a consensus on oral drugsfor Chinese BCL patients on the basis of the current application status of oral drugs in China, combinedThis consensus reviewed the application of oral drugs in the treatment of BCL and the latest researchand provided appropriate recommendations on the use of oral drugs for indolent or aggressive BCL patients

Keywords： B-cell lymphoma     oral drug     targeted therapy     immunotherapy     COVID-19 pandemic    

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nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic acid drugs

Vaibhav Mundra, Ram I. Mahato

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 387-404 doi: 10.1007/s11705-014-1457-3

Abstract: challenges in developing efficient and target specific delivery systems of small molecule and nucleic acid drugs

Keywords： nanocarrier     cellular uptake     endosomal release     nucleic acid drug    

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Current recommendations of managing HBV infection in preconception or pregnancy

James S. Park,Calvin Pan

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 158-165 doi: 10.1007/s11684-014-0340-4

Abstract: The emerging data suggest that initiation of antiviral therapy in the beginning of the third trimesterIn order to minimize the fetal exposure to the antiviral medication, antiviral therapy during the pregnancyand after the pregnancy; the risk factors that increase mother-to-child transmission; safety data on antiviral

Keywords： antiviral therapy     Caesarean section     cirrhosis     hepatitis B     immunoprophylaxis     mother-to-child transmission    

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Oral administration of

Sufen ZHAO,Yuanyuan JIA,Weiwei ZHANG,Lili WANG,Yunfei MA,Kedao TENG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 4,   Pages 318-326 doi: 10.15302/J-FASE-2015080

Abstract: Garlic ( Liliaceae) has been safely used for more than 5000 years, and research on garlic extract is rapidly increasing because of its multiple biological functions. The effects of oral administration of garlic mixture (GM, water-soluble extract) on infectious bursal disease virus (IBDV)-infected specific pathogen free male white leghorn chicken were examined through histopathological, immunohistochemical, and Western blot analyses, and enzyme-linked immunosorbent assay. The results confirmed the protective effects of oral administration of 5 mg·kg BW GM (Group GM1) on bursal lesions after IBDV infection. In particular, protein expression of IBDV in the bursa decreased in Group GM1, indicating that GM administration decreased IBDV replication in the bursa. Furthermore, immunoglobulin M- and A-bearing B lymphocytes significantly increased 7 days post infection in bursae in Group GM1 ( <0.01), suggesting that the oral administration of 5 mg·kg GM offers moderate protection against B cell destruction after IBDV infection. During infection, the concentration of bursal interferon gamma (IFN-g) increased and peaked in Group GM1 earlier than in Group T (IBDV-exposed), demonstrating that GM administration prompted the production of IFN-g to protect against IBDV infection.

Keywords： garlic     infectious bursal disease virus (IBDV)     antiviral effect     IgM-bearing B lymphocyte    

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Telomeric impact of conventional chemotherapy

Yiming Lu, Waiian Leong, Olivier Guérin, Eric Gilson, Jing Ye

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 411-417 doi: 10.1007/s11684-013-0293-z

Abstract: telomere stability can be more affected than the bulk of the genome by several conventional antineoplasic drugsThese results raise the interesting possibility that CT with genotoxic drugs preferentially target telomeres

Keywords： telomere     antineoplasic drugs     conventional chemotherapies    

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Title Author Date Type Operation

Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

Journal Article

Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection

Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang

Journal Article

Direct acting antiviral-induced dynamic reduction of serum

Tung Huynh, Ke-Qin Hu

Journal Article

ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT

Journal Article

Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Journal Article

ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT

Wentao XU, Hao TIAN, Hongjian SONG, Yuxiu LIU, Yongqiang LI, Qingmin WANG

Journal Article

Occurrence, distribution and risk assessment of abused drugs and their metabolites in a typical urban

Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu

Journal Article

Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

Journal Article

ANTIVIRAL EFFECTS OF BACTERIOCIN AGAINST ANIMAL-TO-HUMAN TRANSMITTABLE MUTATED SARS-COV-2: A SYSTEMATIC

Journal Article

Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Journal Article

nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic acid drugs

Vaibhav Mundra, Ram I. Mahato

Journal Article

Current recommendations of managing HBV infection in preconception or pregnancy

James S. Park,Calvin Pan

Journal Article

Oral administration of

Sufen ZHAO,Yuanyuan JIA,Weiwei ZHANG,Lili WANG,Yunfei MA,Kedao TENG

Journal Article

Telomeric impact of conventional chemotherapy

Yiming Lu, Waiian Leong, Olivier Guérin, Eric Gilson, Jing Ye

Journal Article

A Review of the International Workshop on “Technological Upgradation of Drugs/Pharmaceutical & Agrochemical

LI Zhengming

Journal Article